This is the largest ever nursing care trial every conducted with the target sample size of over 19,000 patients.
HeadPoST is an international, multicentre, prospective, cluster randomised crossover controlled trial to be undertaken across 140 hospitals in several countries. Hospitals will participate from the UK, South America, Australia, China, Europe and Mongolia, recruiting 70 consecutive stroke patients per intervention phase. The study is currently being piloted in Chile, Australia and the UK.
The primary aim is to compare the effects of lying flat (0°) head position with sitting up (≥30°) head position applied in the first 24 hours of admission, for patients presenting with acute stroke, on the poor outcome of death or disability at 90 days.
The trial uses a Cluster guardian consent process for the intervention at each hospital for the adoption of the intervention as usual stroke care during the trial period. Consent for data collection and follow-up will be obtained from individual patients.
Data collection will be from admission until discharged and a 90 day blinded follow-up assessment.
The trial run from 2014 to 2016 with recruitment expected to start at the end of 2014 and close out by mid -2016.